皮肉分離現象常見於臉頰、下巴線條及眼周,讓輪廓、鬆弛下垂,整體視覺年齡顯得疲憊、缺乏朝氣。JULÄINE™ 採用高純度的聚左乳酸(PLLA) 作為核心成分,通過激活纖維母細胞,促進 I 型與 III 型膠原蛋白的生成⁴。這一技術不僅能顯著改善肌膚彈性,還能全面提升膚質,改善皮肉分離問題,讓肌膚恢復緊緻光滑的年輕狀態。
2025. Urdiales et al. Facial Rejuvenation With an Innovative Poly-l-Lactic Acid (Juläine) for Nasolabial Folds: Interim Data Analysis of a Prospective, Non-Randomized, Multicenter, Open-Label Spanish Study, Journal of Cosmetic Dermatology, 2025; 24:e70137.
2025. GR21-027. JULÄINE™ Instructions for Use. V4. 24.01.2025.
2020. Gao et Al. Superiority of poly(l-lactic acid) microspheres as dermal fillers. CCL 2020.03.071.
2023. Zhu & Dong. Poly-L-Lactic Acid increases collagen gene expression and synthesis in cultured fibroblasts (HS68) through the TGF-B/Smad pathway. J. Cosmetic Dermatology 2023;22:1213–1219.
2025. Kubik et al. Comparative Analysis of Reconstitution and Solubility of Two Poly-L-Lactic Acid Fillers for Medical Applications. Polymers 2025, 17, 1778.
2023. The effect of PLLA particles usability, technical and clinical perspectives. Study performed by Research Institute of Sweden AB (RISE). Data on file.